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Malaria in the Greater Mekong Subregion: Heterogeneity and complexity

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WOS被引频次:108
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成果类型:
期刊论文
作者:
Cui, Liwang;Yan, Guiyun;Sattabongkot, Jetsumon;Cao, Yaming;Chen, Bin;Chen, Xiaoguang;Fan, Qi;Fang, Qiang;Jongwutiwes, Somchai;Parker, Daniel;Sirichaisinthop, Jeeraphat;Kyaw, Myat Phone;Su, Xin-zhuan;Yang, Henglin;Yang, Zhaoqing;Wang, Baomin;Xu, Jianwei;Zheng, Bin;Zhong, Daibin;Zhou, Guofa
通讯作者:
Cui, LW
作者机构:
[Chen, Xiaoguang] So Med Univ, Sch Publ Hlth & Trop Med, Dept Etiobiol, Guangzhou 510515, Guangdong, Peoples R China.
[Wang, Baomin] China Agr Univ, Coll Agron & Biotechnol, Beijing 100193, Peoples R China.
[Cao, Yaming] China Med Univ, Coll Basic Med Sci, Dept Immunol, Shenyang, Peoples R China.
[Yan, Guiyun; Zhou, Guofa; Zhong, Daibin] Univ Calif Irvine, Program Publ Hlth, Irvine, CA 92697 USA.
[Yan, Guiyun; Chen, Bin; Cui, Liwang] Chongqing Normal Univ, Coll Life Sci, Chongqing 400047, Peoples R China.
通讯机构:
[Cui, LW] Penn State Univ, Dept Entomol, 501 ASI Bldg, University Pk, PA 16801 USA.
语种:
英文
关键词:
Malaria;The Greater Mekong Subregion;Epidemiology;Anopheles vectors;Drug resistance;Border malaria;Elimination
期刊:
ACTA TROPICA
ISSN:
0001-706X
年:
2012
卷:
121
期:
3
页码:
227-239
文献类别:
WOS:Article
所属学科:
ESI学科类别:临床医学;WOS学科类别:Parasitology;Tropical Medicine
入藏号:
基金类别:
National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) [U19 AI089672]; Division of Intramural Research, NIAID, NIH
机构署名:
本校为其他机构
院系归属:
基础医学院
公共卫生学院
摘要:
The Greater Mekong Subregion (GMS), comprised of six countries including Cambodia, China's Yunnan Province, Lao PDR, Myanmar (Burma), Thailand and Vietnam, is one of the most threatening foci of malaria. Since the initiation of the WHO's Mekong Malaria Program a decade ago, malaria situation in the GMS has greatly improved, reflected in the continuous decline in annual malaria incidence and deaths. However, as many nations are moving towards malaria elimination, the GMS nations still face great challenges. Malaria epidemiology in this region exhibits enormous geographical heterogeneity with Myanmar and Cambodia remaining high-burden countries. Within each country, malaria distribution is also patchy, exemplified by 'border malaria' and 'forest malaria' with high transmission occurring along international borders and in forests or forest fringes, respectively. 'Border malaria' is extremely difficult to monitor, and frequent malaria introductions by migratory human populations constitute a major threat to neighboring, malaria-eliminating countries. Therefore, coordination between neighboring countries is essential for malaria elimination from the entire region. In addition to these operational difficulties, malaria control in the GMS also encounters several technological challenges. Contemporary malaria control measures rely heavily on effective chemotherapy and insecticide control of vector mosquitoes. However, the spread of multidrug resistance and potential emergence of artemisinin resistance in Plasmodium falciparum make resistance management a high priority in the GMS. This situation is further worsened by the circulation of counterfeit and substandard artemisinin-related drugs. In most endemic areas of the GMS, P. falciparum and Plasmodium vivax coexist, and in recent malaria control history, P. vivax has demonstrated remarkable resilience to control measures. Deployment of the only registered drug (primaquine) for the radical cure of vivax malaria is severely undermined due to high prevalence of glucose-6-phosphate dehydrogenase deficiency in target human populations. In the GMS, the dramatically different ecologies, diverse vector systems, and insecticide resistance render traditional mosquito control less efficient. Here we attempt to review the changing malaria epidemiology in the GMS, analyze the vector systems and patterns of malaria transmission, and identify the major challenges the malaria control community faces on its way to malaria elimination. (C) 2011 Elsevier B.V. All rights reserved.
参考文献:
Amin AA, 2007, J CLIN PHARM THER, V32, P429
Anderson TJC, 2005, ACTA TROP, V94, P269, DOI 10.1016/j.actatropica.2005.04.010
Caudron JM, 2008, TROP MED INT HEALTH, V13, P1062, DOI 10.1111/j.1365-3156.2008.02106.x
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