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Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

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成果类型:
期刊论文
作者:
Han, Jian-Wen;Zheng, Hou-Feng;Cui, Yong;Sun, Liang-Dan;Ye, Dong-Qing;Hu, Zhi;Xu, Jin-Hua;Cai, Zhi-Ming;Huang, Wei;Zhao, Guo-Ping;Xie, Hong-Fu;Fang, Hong;Lu, Qian-Jin;Xu, Jian-Hua;Li, Xiang-Pei;Pan, Yun-Feng;Deng, Dan-Qi;Zeng, Fan-Qin;Ye, Zhi-Zhong;Zhang, Xiao-Yan;Wang, Qing-Wen;Hao, Fei;Ma, Li;Zuo, Xian-Bo;Zhou, Fu-Sheng;Du, Wen-Hui;Cheng, Yi-Lin;Yang, Jian-Qiang;Shen, Song-Ke;Li, Jian;Sheng, Yu-Jun;Zuo, Xiao-Xia;Zhu, Wei-Fang;Gao, Fei;Zhang, Pei-Lian;Guo, Qing;Li, Bo;Gao, Min;Xiao, Feng-Li;Quan, Cheng;Zhang, Chi;Zhang, Zheng;Zhu, Kun-Ju;Li, Yang;Hu, Da-Yan;Lu, Wen-Sheng;Huang, Jian-Lin;Liu, Sheng-Xiu;Li, Hui;Ren, Yun-Qing;Wang, Zai-Xing;Yang, Chun-Jun;Wang, Pei-Guang;Zhou, Wen-Ming;Lv, Yong-Mei;Zhang, An-Ping;Zhang, Sheng-Quan;Lin, Da;Li, Yi;Low, Hui Qi;Shen, Min;Zhai, Zhi-Fang;Wang, Ying;Zhang, Feng-Yu;Yang, Sen;Liu, Jian-Jun;Zhang, Xue-Jun
通讯作者:
Zhang, XJ
作者机构:
[Cheng, Yi-Lin; Li, Yang; Cui, Yong; Liu, Jian-Jun; Li, Hui; Hu, Da-Yan; Li, Jian; Sun, Liang-Dan; Zhang, Feng-Yu; Zhang, Chi; Sheng, Yu-Jun; Zhou, Fu-Sheng; Zhang, An-Ping; Yang, Sen; Yang, Jian-Qiang; Xiao, Feng-Li; Du, Wen-Hui; Gao, Min; Hu, Zhi; Zhang, Sheng-Quan; Liu, Sheng-Xiu; Lin, Da; Shen, Song-Ke; Han, Jian-Wen; Zuo, Xian-Bo; Quan, Cheng; Ye, Dong-Qing; Lu, Wen-Sheng; Lv, Yong-Mei; Zhou, Wen-Ming; Zhang, Xue-Jun; Zhang, Zheng; Wang, Pei-Guang; Zhu, Kun-Ju; Wang, Zai-Xing; Ren, Yun-Qing; Zheng, Hou-Feng; Yang, Chun-Jun] Anhui Med Univ, Hosp 1, Inst Dermatol, Hefei, Anhui, Peoples R China.
[Cheng, Yi-Lin; Li, Yang; Cui, Yong; Liu, Jian-Jun; Li, Hui; Hu, Da-Yan; Li, Jian; Sun, Liang-Dan; Zhang, Feng-Yu; Zhang, Chi; Sheng, Yu-Jun; Zhou, Fu-Sheng; Zhang, An-Ping; Yang, Sen; Yang, Jian-Qiang; Xiao, Feng-Li; Du, Wen-Hui; Gao, Min; Hu, Zhi; Zhang, Sheng-Quan; Liu, Sheng-Xiu; Lin, Da; Shen, Song-Ke; Han, Jian-Wen; Zuo, Xian-Bo; Quan, Cheng; Ye, Dong-Qing; Lu, Wen-Sheng; Lv, Yong-Mei; Zhou, Wen-Ming; Zhang, Xue-Jun; Zhang, Zheng; Wang, Pei-Guang; Zhu, Kun-Ju; Wang, Zai-Xing; Ren, Yun-Qing; Zheng, Hou-Feng; Yang, Chun-Jun] Anhui Med Univ, Hosp 1, Dept Dermatol, Hefei, Anhui, Peoples R China.
[Cheng, Yi-Lin; Li, Yang; Cui, Yong; Liu, Jian-Jun; Li, Hui; Hu, Da-Yan; Li, Jian; Sun, Liang-Dan; Zhang, Feng-Yu; Zhang, Chi; Sheng, Yu-Jun; Zhou, Fu-Sheng; Zhang, An-Ping; Yang, Sen; Yang, Jian-Qiang; Xiao, Feng-Li; Du, Wen-Hui; Gao, Min; Hu, Zhi; Zhang, Sheng-Quan; Liu, Sheng-Xiu; Lin, Da; Shen, Song-Ke; Han, Jian-Wen; Zuo, Xian-Bo; Quan, Cheng; Ye, Dong-Qing; Lu, Wen-Sheng; Lv, Yong-Mei; Zhou, Wen-Ming; Zhang, Xue-Jun; Zhang, Zheng; Wang, Pei-Guang; Zhu, Kun-Ju; Wang, Zai-Xing; Ren, Yun-Qing; Zheng, Hou-Feng; Yang, Chun-Jun] Anhui Med Univ, Minist Educ, Key Lab Dermatol, Hefei, Anhui, Peoples R China.
[Xie, Hong-Fu; Zuo, Xiao-Xia] Cent S Univ, Xiangya Hosp, Dept Dermatol, Changsha, Hunan, Peoples R China.
[Gao, Fei; Lu, Qian-Jin] Cent S Univ, Epigenet Res Ctr, Dept Dermatol, Xiangya Hosp 2, Changsha, Hunan, Peoples R China.
通讯机构:
[Zhang, XJ] Anhui Med Univ, Hosp 1, Inst Dermatol, Hefei, Anhui, Peoples R China.
语种:
英文
期刊:
NATURE GENETICS
ISSN:
1061-4036
年:
2009
卷:
41
期:
11
页码:
1234-U98
文献类别:
WOS:Article
所属学科:
ESI学科类别:分子生物学&遗传学;WOS学科类别:Genetics & Heredity
入藏号:
基金类别:
National Natural Science Foundation [30972727, 30530670, 30830089]; Anhui Provincial Special Scientific Program [2007-7]; Anhui Skin Genetic Study Innovative Research Team Program [TD200701]
机构署名:
本校为其他机构
院系归属:
第一临床医学院
第二临床医学院
临床肿瘤学院
摘要:
We performed a genome-wide association study (GWAS) of systemic lupus erythematosus (SLE) in a Chinese Han population by genotyping 1,047 cases and 1,205 controls using Illumina Human610-Quad BeadChips and replicating 78 SNPs in two additional cohorts (3,152 cases and 7,050 controls). We identified nine new susceptibility loci (ETS1, IKZF1, RASGRP3, SLC15A4, TNIP1, 7q11.23, 10q11.22, 11q23.3 and 16p11.2; 1.77 x 10(-25) <= P(combined) <= 2.77 x 10(-8)) and confirmed seven previously reported loci (BLK, IRF5, STAT4, TNFAIP3, TNFSF4, 6q21 and 22q11.21; 5.17 x 10(-42) <= P(combined) <= 5.18 x 10(-12)). Comparison with previous GWAS findings highlighted the genetic heterogeneity of SLE susceptibility between Chinese Han and European populations. This study not only advances our understanding of the genetic basis of SLE but also highlights the value of performing GWAS in diverse ancestral populations.
参考文献:
Lee J, 2009, J BIOL CHEM, V284, P23818, DOI 10.1074/jbc.M109.033670
Price AL, 2006, NAT GENET, V38, P904, DOI 10.1038/ng1847
Chu JY, 1998, P NATL ACAD SCI USA, V95, P11763, DOI 10.1073/pnas.95.20.11763
Coughlin JJ, 2005, J IMMUNOL, V175, P7179
GEORGOPOULOS K, 1994, CELL, V79, P143, DOI 10.1016/0092-8674(94)90407-3

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