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Cationic Iridium(III) Complexes with Tunable Emission Color as Phosphorescent Dyes for Live Cell Imaging

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成果类型:
期刊论文
作者:
Qiang Zhao;Mengxiao Yu;Linxi Shi;Shujuan Liu;Chunyan Li;Mei Shi;Zhiguo Zhou;Chunhui Huang;Fuyou Li
通讯作者:
Li, F.(fyli@fudan.edu.cn)
作者机构:
[Linxi Shi] Department of Microbiology and Immunology, Kunming Medical College, Kunming 650031, China
[Mengxiao Yu; Qiang Zhao; Zhiguo Zhou; Fuyou Li; Chunyan Li; Chunhui Huang; Mei Shi] Department of Chemistry, Fudan University, Shanghai 200433, China
[Qiang Zhao; Shujuan Liu] Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210003, China
通讯机构:
[Li, FY] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China.
语种:
英文
关键词:
Bio-imaging - Cell membrane permeability - Conjugated length - Difluorophenyl - Emission color - Excitation wavelength - Excited-state properties - Fluorescence probes - Fluorescent probes - High quantum efficiency - Iridium complex - Live-cell imaging - Living cell imaging - Long lifetime - N ligands - Phosphorescent dyes - Stokes shift - Triplet energy - Tunable emissions
期刊:
Organometallics
ISSN:
0276-7333
年:
2010
卷:
29
期:
5
页码:
1085-1091
文献类别:
WOS:Article;EI:Journal article (JA)
所属学科:
ESI学科类别:化学;WOS学科类别:Chemistry, Inorganic & Nuclear;Chemistry, Organic
入藏号:
WOS:000274841600006;EI:20101012759995
基金类别:
National Natural Science Foundation of China [20775017, 50803028]; National Natural Science Funds for Distinguished Young Scholars [20825101, NCET-06-0353]; Shanghai Leading Academic Discipline Project [B108]
机构署名:
本校为其他机构
院系归属:
基础医学院
摘要:
Phosphorescent heavy-metal complexes exhibit relatively long lifetimes and significant Stokes shifts for easy separation of excitation and emission and could be used as promising candidates for fluorescence probes. To date, however, very limited examples of the use of phosphorescent heavy-metal complexes in bioimaging have been reported. Herein, a series of cationic iridium(III) complexes, [Ir(dfpy)<inf>2</inf>L]<sup>+</sup>PF<inf>6</inf><sup>-</sup> (dfpy = 2-(2,4-difluorophenyl)pyridine;L denotes a series of N&and;N ligands with different conjugated lengths), have been synthesized. By variation of the N&and;N ligands, the emission colors of these complexes can be tuned from blue to red, while high quantum efficiencies are retained. Further investigation reveals that these complexes exhibit different excited-state properties, which are responsible for the significant emission color tuning. Moreover, the exclusive staining of cytoplasm and low cytotoxicity were observed for these cationic iridium(III) complexes, as well as good cell membrane permeability, which makes them promising candidates as fluorescent probes for living cell imaging. Furthermore, in order to tune the excitation wavelength to the longer region, another cationic iridium(III) complex with lower singlet and triplet energy levels was also investigated to be used as living cell imaging material, achieving a longer excitation wavelength of 488 nm. &copy;2010 American Chemical Society.
参考文献:
Adachi C, 2001, APPL PHYS LETT, V79, P2082, DOI 10.1063/1.1400076
Amoroso AJ, 2007, CHEM COMMUN, P3066, DOI 10.1039/b706657k
BANKS PR, 1995, BIOCONJUGATE CHEM, V6, P447, DOI 10.1021/bc00034a015
Boyer D, 2002, SCIENCE, V297, P1160, DOI 10.1126/science.1073765
Bruchez M, 1998, SCIENCE, V281, P2013, DOI 10.1126/science.281.5385.2013

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